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Key hallmarks and molecular mechanisms of aging In 2023, researchers integrated and elaborated on 12 characteristics of aging, 39 including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis
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